Metabolic and genetic aspects of thiopurine metabolism

dr. J.A. Bakker

Chapter 01 – Introduction

Chapter 02 – Selectivity of TPMT towards thiopurine nucleosides and nucleotides

Chapter 03 – Quantitative measurement of thiopurine metabolites in biological fluids using ultraperformance liquid chromatographytandem mass spectometry

Chapter 04 – Azathioprine induced pneumonitis in a patient with ulcerative colitis

Chapter 05 – A comparative study of inosine triphosphatase activity in fresh erythrocytes and dried blood spots

Chapter 06 – The effect of ITPA polymorphisms on the enzyme kinetic properties of human erythrocyte inosine triphosphatase towards its substrates ITP and 6-thio-ITP Effects of ITPA polymorphism on ITPase kinetics

Chapter 07 – Role for ITPA variants in the clinical course of pulmonary Langerhans’cell histiocytosis? ITPA polymorphisms in PLCH

Chapter 08 – General discussion

Chapter 09 – Summary

Chapter 10 – Samenvatting

Chapter 11 – List of publications

Chapter 12 – Dankwoord

Chapter 13 – Curriculum vitae

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